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During breastfeeding, this requirement increases to 2.0 g per day to ensure adequate B12 content in breast milk

Removal from Category 2 is a step, not a clearance

Structural modifications allow them to stay in circulation for hours or even days: IGF-1 LR3 : 2030 hour half-life CJC-1295 with DAC : 58 day half-life PEG-MGF : detectable for up to 12 weeks Pharmacokinetic enhancements such as PEGylation or fatty acid acylation extend the peptides residence time, reduce renal clearance, and improve therapeutic utility. Veronese & Mero, BioDrugs What Determines How Long Peptides Stay in Your System

Since it is not a surgical procedure, there is no significant downtime required